eMule Anleitung are under investigation for use as clinical drugs to treat muscle-wasting conditions such as cancer cachexia and osteoporosis. They can also be used to improve quality of life in patients with serious and therapy-deficient diseases such as benign prostatic hyperplasia and stress urinary incontinence (SUI). SARMs have the potential to be more efficacious than testosterone in treating some conditions, such as prostate cancer (PCa), because of their ability to preferentially stimulate bone and muscle growth while limiting side effects of androgenic activity. This differential tissue selectivity may be related to their pharmacophore structure, interaction with 5a-reductase or CYP19 aromatase, and tissue-specific expression of coregulators.

The FDA continues to receive reports of serious side effects associated with the use of SARMs, including testicular shrinkage and sexual dysfunction, as well as cardiovascular problems and psychoses. Many of these cases involve unregulated SARMs sold by online vendors and through social media influencers. The FDA warns that these products are illegal to sell without a prescription and can cause dangerous side effects, including heart attacks, strokes, liver failure and testicular cancer.

Real Experiences: User Stories and Transformations with SARMs

The use of SARMs in doping has been banned by the World Anti-Doping Agency, and they are also commonly available on internet-based gray markets and are widely used for recreational purposes. They can be administered orally or topically, as long as the dose is well below what would be used in clinical practice. Several SARMs have been tested in preclinical and clinical studies, but none have been approved by the FDA.